故事围绕一名年约30多岁的女子Piper Chapman展开，她本来正在纽约过着守秩序的安稳生活，但因在多年前协助毒品走私犯兼前女友Alex Vause运毒，在某日突然被起诉过去的罪行继而入狱。在监狱中，Piper与Alex重遇，期间重新审视两人关系。与此同时，Piper和其他囚犯还需要与监狱里的众多黑暗做斗争。 剧集中展示了美国监狱各种形式的腐败，包括监狱私有化、人满为患、狱警的虐待行为和种族歧视，以及监狱无法履行其作为惩戒机关的基本法律责任和道德义务等其他问题。

Before everyone's favorite felons became THE Bad Guys, they were just some bad guys trying to earn their fearsome reputation. On their journey to be the biggest and baddest criminals in history, Wolf makes it their mission to become the top crew on 6 News