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卢修女早已失去信仰，她登上从蒙特利尔开往纽约的高速列车，同行的还有经验丰富的诺瓦克神父。列车行驶途中，一股强大的恶魔力量附身乘客，邪物化身阿斯蒙蒂斯让列车失控，朝着毁灭的方向疾驰。封闭车厢内，乘客接连被附身，危机层层蔓延。没有退路也没有外援，陆修女必须直面破碎的信仰，在失控的列车上，为被附身的乘客执行驱魔仪式，对抗不断扩散的邪恶，阻止这场列车上的死亡灾难。
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泰国郊外的古庙有个可怕的诅咒。年轻盗墓者欧弟，在古庙挖出一条二战时期的黄金脚炼，占为己有的他因此触犯诅咒，身体肌肤变成蛇鳞，强大的诅咒让他十分痛苦，也再次召唤出古墓厉鬼。在与寻求复仇的恶鬼时间赛跑中，因诅咒缠身快死的阿弟，与狐群狗党噗咙共好友们，布伦、阿一、玄兵，以及潘潘，将远赴泰国东北湄公河一座传说中的雨林古寺，寻找破解诅咒的秘密。
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Big Baby tells the story of Adam Lewis, a successful horror screenwriter struggling for inspiration for his latest script. After a graphic and realistic nightmare of a hulking man dressed in a baby mask and onesie who axe murders his girlfriend Kate in the middle of the night, Adam gets the inspiration he needs for his new screenplay. Excited about the direction his story is taking, he starts losing himself in his script. Things are better than ever for Adam and Kate until “Big Baby” starts appearing in real life and tormenting and killing victims fueled by his own revenge. Characters from Adam’s script begin to pay him visits pleading for their lives, and he quickly realizes he holds their fate in his hands. Power and fear completely consume Adam until his girlfriend Kate is terrified of the man she once loved.